abstract：BACKGROUND:Positron emission tomography (PET) and PET/computed tomography (PET/CT) imaging with 3,4-dihydroxy-6-[18F] fluoro-L-phenylalanine (18F-FDOPA) has been used in the evaluation of gliomas. We performed a meta-analysis to obtain the diagnostic and grading accuracy of 18F-FDOPA PET and PET/CT in patients with gli...

journal_title：BMC cancer

authors： Xiao J,Jin Y,Nie J,Chen F,Ma X

更新日期：2019-08-05 00:00:00

abstract：BACKGROUND:Breast cancer is the most common cancer type in female. As microRNAs play vital role in breast cancer, this study aimed to explore the molecular mechanism and clinical value of miR-21 in breast cancer. METHODS:qRT-PCR was performed to detect miR-21 levels in plasma of 127 healthy controls, 82 benign breast ...

journal_title：BMC cancer

authors： Wang H,Tan Z,Hu H,Liu H,Wu T,Zheng C,Wang X,Luo Z,Wang J,Liu S,Lu Z,Tu J

更新日期：2019-07-27 00:00:00

abstract：BACKGROUND:Fast-track colonoscopy to detect patients with colorectal cancer based on high-risk symptoms is associated with low sensitivity and specificity. The aim was to derive a predictive score of advanced colonic neoplasia in symptomatic patients in fast-track programs. METHODS:All patients referred for fast-track...

journal_title：BMC cancer

authors： Fernández-Bañares F,Clèries R,Boadas J,Ribes J,Oliva JC,Alsius A,Sanz X,Martínez-Bauer E,Galter S,Pujals M,Pujol M,Del Pozo P,Campo R

更新日期：2019-07-25 00:00:00

abstract：BACKGROUND:Immune checkpoint inhibitors (ICIs) were approved to have a significant antitumor activity in various tumor types. In practice, some patients do not seem to benefit from ICIs but rather to have accelerating disease. The aim of this study was to evaluate hyperprogression in patients with malignant tumors of d...

journal_title：BMC cancer

authors： Ji Z,Peng Z,Gong J,Zhang X,Li J,Lu M,Lu Z,Shen L

更新日期：2019-07-17 00:00:00

abstract：BACKGROUND:To evaluate the safety and efficacy of intra-arterial chemotherapy (IAC) for the primary or secondary treatment of infants diagnosed with advanced retinoblastoma before 3 months of age. METHODS:This single-center retrospective study included 39 infants (42 eyes) aged ≤3 months who were diagnosed with unilat...

journal_title：BMC cancer

authors： Chen Q,Zhang B,Dong Y,Mo X,Zhang L,Xia J,Zhang J,Zhang S

更新日期：2019-07-15 00:00:00

abstract：BACKGROUND:Oesophagectomy remains the only curative intervention for oesophageal cancer, with defined nutritional and health-related quality of life (HR-QOL) consequences. It follows therefore that there is a significant risk of decline in physical wellbeing with oesophagectomy however this has been inadequately quanti...

journal_title：BMC cancer

authors： Guinan EM,Bennett AE,Doyle SL,O'Neill L,Gannon J,Foley G,Elliott JA,O'Sullivan J,Reynolds JV,Hussey J

更新日期：2019-07-12 00:00:00

abstract：BACKGROUND:The literature on sexual orientation disclosure is arguably one of the most developed in the field of lesbian, gay and bisexual (LGB) people in healthcare in English speaking countries however, relatively little research has been conducted into disclosure in cancer care. Studies have been mainly undertaken i...

journal_title：BMC cancer

authors： Fish J,Williamson I,Brown J

更新日期：2019-07-10 00:00:00

abstract：BACKGROUND:Stereotactic radiotherapy is an emerging treatment option for patients with inoperable renal cell carcinoma (RCC). Haemorrhage has not previously been reported to occur as a result of Stereotactic Body Radiotherapy (SBRT) to the kidney for primary RCC. We report an acute haemorrhage in a patient who received...

journal_title：BMC cancer

authors： Hilleary LA,Wratten C,Siva S,Hilleary J,Martin JM

更新日期：2019-07-08 00:00:00

abstract：BACKGROUND:In order to maximize later health, there are established components and guidelines for quality follow-up care of breast cancer survivors. However, adherence to quality follow-up in Canada may not be optimal, and may vary by province. We determined and compared the proportion of patients in each province who ...

journal_title：BMC cancer

authors： McBride ML,Groome PA,Decker K,Kendell C,Jiang L,Whitehead M,Li D,Grunfeld E,CanIMPACT Team.

更新日期：2019-07-04 00:00:00

abstract：BACKGROUND:Studies have consistently indicated that the majority of individuals meeting the US Prevention Services Task Force guidelines for genetic testing have not had genetic counseling or testing. Despite increased availability and lower costs of multiplex cancer gene panels, there remains a gap in genetics service...

journal_title：BMC cancer

authors： Rayes N,Bowen DJ,Coffin T,Nebgen D,Peterson C,Munsell MF,Gavin K,Lechner R,Crase J,Polinsky D,Romero I,Blank SV,Levine DA,Norquist BM,Swisher EM,Lu KH

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:Altered expression of microRNAs (miRNAs) is known to contribute to cancer progression. miR-23b and miR-27b, encoded within the same miRNA cluster, are reported to have both tumor suppressive and oncogenic activity across human cancers, including breast cancer. METHODS:To clarify this dichotomous role in bre...

journal_title：BMC cancer

authors： Hannafon BN,Cai A,Calloway CL,Xu YF,Zhang R,Fung KM,Ding WQ

更新日期：2019-06-28 00:00:00

abstract：:Following publication of the original article [1], the authors reported the following errors in the article. ...

journal_title：BMC cancer

authors： Perez EA,de Haas SL,Eiermann W,Barrios CH,Toi M,Im YH,Conte PF,Martin M,Pienkowski T,Pivot XB,Burris HA 3rd,Stanzel S,Patre M,Ellis PA

更新日期：2019-06-24 00:00:00

abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) represent the majority of cellular transcripts and play pivotal roles in hematopoiesis. However, their clinical relevance in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) remains largely unknown. Here, we investigated the functions of HOXB-AS3, a lncRNA locate...

journal_title：BMC cancer

authors： Huang HH,Chen FY,Chou WC,Hou HA,Ko BS,Lin CT,Tang JL,Li CC,Yao M,Tsay W,Hsu SC,Wu SJ,Chen CY,Huang SY,Tseng MH,Tien HF,Chen RH

更新日期：2019-06-24 00:00:00

abstract：BACKGROUND:Currently, there are three main surgical approaches for resectable esophageal cancer: open transthoracic esophagectomy (OTE), conventional minimally invasive esophagectomy (MIE) and robot-assisted esophagectomy (RAE). Previous studies had demonstrated the better short-term outcomes in MIE or RAE when compare...

journal_title：BMC cancer

authors： Yang Y,Zhang X,Li B,Li Z,Sun Y,Mao T,Hua R,Yang Y,Guo X,He Y,Li H,Chen H,Tan L

更新日期：2019-06-21 00:00:00

abstract：BACKGROUND:Whether chronic inflammation increases prostate cancer risk remains unclear. This study investigated whether chronic inflammatory diseases (CID) or anti-inflammatory medication use (AIM) were associated with prostate cancer risk. METHODS:Fifty-five thousand nine hundred thirty-seven cases (all prostate canc...

journal_title：BMC cancer

authors： Beckmann K,Russell B,Josephs D,Garmo H,Haggstrom C,Holmberg L,Stattin P,Van Hemelrijck M,Adolfsson J

更新日期：2019-06-21 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor exon 20 insertion (EGFRex20ins) mutations represent approximately 4-12% of EGFR mutations and are generally refractory to the 1st and 2nd generation EGFR tyrosine kinase inhibitors (TKIs). Development of effective therapies for patients with EGFRex20ins mutant non-small-cell ...

journal_title：BMC cancer

authors： Fang W,Huang Y,Hong S,Zhang Z,Wang M,Gan J,Wang W,Guo H,Wang K,Zhang L

更新日期：2019-06-17 00:00:00

abstract：BACKGROUND:Prenylated Rab acceptor 1 domain family, member 2 (PRAF2) is involved in the occurrence and progression of several malignant tumors. However, its potential role in esophageal squamous cell carcinoma (ESCC) is still unknown. METHODS:PRAF2 mRNA expression was determined in 77 frozen ESCC samples by quantitati...

journal_title：BMC cancer

authors： Qian Z,Wei B,Zhou Y,Wang Q,Wang J,Sun Y,Gao Y,Chen X

更新日期：2019-06-14 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) is a type of breast cancer with a high degree of malignancy. Because of the remarkable biological characteristics of high invasion, metastasis and recurrence, TNBC is often accompanied by a poor prognosis. As a molecular characteristic of TNBC, high expression of CD147 ha...

journal_title：BMC cancer

authors： Wang C,Xu C,Niu R,Hu G,Gu Z,Zhuang Z

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:Thyroid transcription factor (TTF)-1 expression is a diagnostic marker and a good prognostic indicator for lung adenocarcinoma. However, its good prognostic ability might be due to epidermal growth factor receptor (EGFR)-sensitizing mutations as shown by the positive correlation between TTF-1 expression and ...

journal_title：BMC cancer

authors： Park JY,Jang SH,Kim HI,Kim JH,Park S,Hwang YI,Jung KS,Seo J,Lee CY,Ko Y,Park YB

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:Patients with hepatocellular carcinoma waiting for liver transplantation are commonly treated with locoregional treatments, such as TACE and ablation, to prevent tumor progression and dropout and to improve long-term outcome after transplantation. We wanted to prospectively assess feasibility of systemic ant...

journal_title：BMC cancer

authors： Eilard MS,Andersson M,Naredi P,Geronymakis C,Lindnér P,Cahlin C,Bennet W,Rizell M

更新日期：2019-06-11 00:00:00

abstract：BACKGROUND:Prostate cancer displays different morphologies which, in turn, affect patient outcome. This fact prompted questions about the lineage relationship between differentiated, more treatable prostate adenocarcinoma and poorly differentiated, less treatable non-adenocarcinoma including small cell carcinoma, and t...

journal_title：BMC cancer

authors： Kanan AD,Corey E,Vêncio RZN,Ishwar A,Liu AY

更新日期：2019-05-30 00:00:00

abstract：BACKGROUND:Hypoxia is an important factor that contributes to tumour aggressiveness and correlates with poor prognosis and resistance to conventional therapy. Therefore, identifying hypoxic environments within tumours is extremely useful for understanding cancer biology and developing novel therapeutic strategies. Seve...

journal_title：BMC cancer

authors： Takei N,Yoneda A,Kosaka M,Sakai-Sawada K,Tamura Y

更新日期：2019-05-29 00:00:00

abstract：BACKGROUND:Aberrant spliced isoforms are specifically associated with cancer progression and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a CRK like proto-oncogene, which encodes a SH2 and SH3 (src homology) domain-containing adaptor protein. CRKL is tightly linked ...

journal_title：BMC cancer

authors： Song Q,Yi F,Zhang Y,Jun Li DK,Wei Y,Yu H,Zhang Y

更新日期：2019-05-27 00:00:00

abstract：:Following publication of the original article [1], the authors reported that the incorrect Fig. 2A was published in the article. The recovery times required to achieve a normal neutrophil count was omitted. The corrected Fig. 2 is given below. ...

journal_title：BMC cancer

authors： Jin M,Hu Y,Wu W,Luo Y,Tan Y,Yu J,Jin A,Yang L,Huang H,Wei G

更新日期：2019-05-23 00:00:00

abstract：BACKGROUND:Sunitinib and pazopanib are extensively used as first-line treatment of metastatic renal cell carcinoma (mRCC). We performed this meta-analysis to assess the anti-tumor effectiveness, toxicity, and total costs of the two drugs among patients with mRCC/advanced RCC (aRCC). MATERIALS AND METHODS:PubMed, Scien...

journal_title：BMC cancer

authors： Deng H,Huang Y,Hong Z,Yuan X,Cao Z,Wei Y,Zhang W

更新日期：2019-05-23 00:00:00

abstract：BACKGROUND:Recent studies have extensively investigated the role of miRNAs in colorectal cancer (CRC), and several associations have been reported. In addition, single nucleotide polymorphisms (SNPs) in promoter regions of miRNAs have been shown to affect miRNA expression. Therefore, we aimed to analyze the effect of m...

journal_title：BMC cancer

authors： Kim EG,Kim JO,Park HS,Ryu CS,Oh J,Jun HH,Kim JW,Kim NK

更新日期：2019-05-22 00:00:00

abstract：BACKGROUND:There are limited effective drugs that can reach the brain to target brain tumors, in particular glioblastoma, which is one of the most difficult cancers to be cured from. Because the overexpression of the sigma-2 receptor is frequently reported in glioma clinical samples and associated with poor prognosis a...

journal_title：BMC cancer

authors： Liu CC,Yu CF,Wang SC,Li HY,Lin CM,Wang HH,Abate C,Chiang CS

更新日期：2019-05-20 00:00:00

abstract：BACKGROUND:Resilience has been linked to psychological adaptation to many challenging life events. The present study aims to explore the level of resilience in oral cancer patients and the key factors associated with resilience, and to evaluate the relationship between resilience and anxiety. METHODS:A multiple center...

journal_title：BMC cancer

authors： Gao Y,Yuan L,Pan B,Wang L

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Everolimus, an inhibitor of mammalian target of rapamycin (mTOR), has been shown to increase the efficacy of endocrine therapies in hormone receptor (HR)-positive metastatic breast cancer. However, because breast cancer is a highly heterogeneous disease, the responses of different patients to everolimus may ...

journal_title：BMC cancer

authors： Yi Z,Ma F,Liu B,Guan X,Li L,Li C,Qian H,Xu B

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Treatment of solid malignancies has been revolutionized with the introduction of immune checkpoint inhibitors (ICIs) and their use is being expanded in therapy of different cancers. However, immune related adverse events (IRAEs) can occur during treatment. These side effects occur due to stimulation of the i...

journal_title：BMC cancer

authors： Khaddour K,Singh V,Shayuk M

更新日期：2019-05-14 00:00:00

abstract：:... ...

journal_title：BMC cancer

authors： Knoerl R,Weller E,Halpenny B,Berry D

更新日期：2019-05-13 00:00:00

abstract：BACKGROUND:pressurized intraperitoneal aerosol chemotherapy (PIPAC), with or without electrostatic precipitation (ePIPAC), was recently introduced in the treatment of peritoneal metastases (PM) from ovarian cancer (OC). Preliminary clinical data are promising, but several methodological issues as well the anticancer ef...

journal_title：BMC cancer

authors： Van de Sande L,Willaert W,Cosyns S,De Clercq K,Shariati M,Remaut K,Ceelen W

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:To validate the robust predictive values of tumor vascularity and hand-foot-skin reaction (HFSR) in combination treatment of transarterial chemoembolization (TACE) and sorafenib for patients with intermediate hepatocellular carcinoma (HCC), and then select the potential candidates who would survive best from...

journal_title：BMC cancer

authors： Wang E,Xia D,Bai W,Yuan J,Li X,Niu J,Yin Z,Xia J,Cai H,Fan D,Han G,Liu L

更新日期：2019-04-30 00:00:00

abstract：BACKGROUND:Wilms' tumor is also called nephroblastoma and is the most common pediatric renal cancer. Several genetic and epigenetic factors have been found to account for the development of Wilms' tumor. MiRNAs play important roles in this tumorigenic process. In the present study, we aimed to investigate the role of m...

journal_title：BMC cancer

authors： Liu Z,He F,OuYang S,Li Y,Ma F,Chang H,Cao D,Wu J

更新日期：2019-04-29 00:00:00

abstract：BACKGROUND:In Ethiopia, the incidence of new cases of breast cancer is currently increasing resulting to high rates of morbidity and mortality. Breast cancer is by far the most common cancer accounting for more than one out of three cancer cases in women and one out of every five in the general population. The study wa...

journal_title：BMC cancer

authors： Deressa BT,Cihoric N,Badra EV,Tsikkinis A,Rauch D

更新日期：2019-04-25 00:00:00

abstract：BACKGROUND:Nonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce pre-mature stop codons into CDSs (coding sequences). Synonymous mutations, however, are intuitively thought to be functionally silent and evolutionarily ...

journal_title：BMC cancer

authors： Chu D,Wei L

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:Phase I trials aim to identify the recommended dose for further development. Health-related quality of life (HRQoL) could be a complement to the usual National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) scale to detect adverse events and define the doses. The objective of thi...

journal_title：BMC cancer

authors： Fiteni F,Ray IL,Ousmen A,Isambert N,Anota A,Bonnetain F

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:The purpose of this review is to update previously published reviews on exercise programming in exercise trials in prostate cancer survivors. We evaluated: 1) the application of the principles of exercise training in prescribed programs; 2) the reporting of the components of the exercise prescription; and 3)...

journal_title：BMC cancer

authors： Neil-Sztramko SE,Medysky ME,Campbell KL,Bland KA,Winters-Stone KM

更新日期：2019-04-05 00:00:00

abstract：BACKGROUND:Solid tumours are less oxygenated than normal tissues. This is called tumour hypoxia and leads to resistance to radiotherapy and chemotherapy. The molecular mechanisms underlying such resistance have been investigated in a range of tumour types, including the adult brain tumours glioblastoma, yet little is k...

journal_title：BMC cancer

authors： Cowman S,Fan YN,Pizer B,Sée V

更新日期：2019-04-03 00:00:00

abstract：BACKGROUND:Expression of Nodal, a member of the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs in a variety of human malignancy. However, little is known about its involvement in ovarian tumorigenesis. Herein, we focused on the functional roles of Nodal in ovarian endome...

journal_title：BMC cancer

authors： Miura R,Yokoi A,Matsumoto T,Oguri Y,Hashimura M,Tochimoto M,Kajita S,Saegusa M

更新日期：2019-04-03 00:00:00